For the second time running, fire swept through shops at the Asafo Market in Kumasi in the Ashanti Region on Saturday night.
This time around a section of the footwear manufacturing area at the main entrance caught fire and spread to the story building.
The cause of the fire is not yet known.
It comes just after about 24 hours after fifty shops were razed down by a blaze which left about 500 traders losing properties worth thousands of cedis.
Officers of the Ghana Fire Service had a difficult time dousing the fire due to the combustible materials in the area.